Alpha-Yohimbine

[iron addict]

Alpha-Y is an analogue of yohimbine, but its potency at the subreceptors of alpha2 differs quite a bit--most notably at the alpha2b and alpha2c adrenergic subreceptors. It is 3 times more potent at alpha2b and 4 times more potent at alpha2c. It is equipotent at alpha2a (45).

Alpha-Y’s superior potency at the other receptors lets us hit them hard, while moderating activity at alpha2a. Alpha2a is the primary receptor subtype, making up 90% (46). It mediates most the classic effects of alpha2 receptor blockade such as increased NE, heart rate, blood pressure, and anxiety (47).

Alpha2a inhibition increases NE by up to 200% while increasing dopamine by only about 80% (48). Disruption of this subreceptor also increases corticosterone (rat version of cortisol) by 100-200% (49). And as we have discussed, these would have negative long-term consequences on the adipostat.

The alpha2c receptor on the other hand, plays only a minor role in the negative feedback signal on NE, but it plays a major role in certain brain areas where sympathetic innervation is low, and the dopamine system is prominent (50). These just happen to be the areas that are critical for reward, reinforcement, and metabolic control, such as the VMH, VTA, and striatum (51). In these areas, dopamine is the primary agonist at alpha2 receptors, and alpha2c makes up the majority of these receptors (52).

Thus, it will block dopamine’s negative feedback signal and increase dopaminergic tone. The dopamine precursor, L-dopa, is higher in alpha2c knockout mice (53). A2c disruption increases, and overexpression decreases, the response to amphetamine stimulation (54). Alpha2c activation (which would decrease dopamine) results in behavioral despair (depression) and elevated cortisol levels (55).

Alpha2c is also the primary subtype in skeletal muscle and an antagonist causes selective femoral vasodilation (56). If that were not handy enough, the only other place the alpha2c subreceptors are highly expressed is in the adrenal medulla, where it modulates negative feedback on epinephrine, much like alpha2a does on NE (57). In other words, in addition to the dopamine increase, Alpha-Y™ allows for a much greater increase in EP levels, with its superior effect on thermogenesis, energy expenditure, and nutrient partitioning. So, we can see that Alpha-yohimbine’s potent antagonism of alpha2c is the good ****.

[Natural Disaster]

Great post.

This is the exact reason we chose Alpha-yohimbine in our product, ALPHA-T2.

Here is a little more "kindergarten" version on the differences of Alpha-yohimbine and regular yohimbine.

Alpha-yohimbine can actually TARGET fat loss. Alpha-yohimbine is much better than regular yohimbine. There are a lot of guys who hate the side effects yohimbine gives them. Well with alpha-yohimbine, you wont feel any of those sides, AND you will get more fatloss benefits.

There are receptors in your stomach, love handles, lower back, and chest called Alpha-2 adrenoceptors (see above post). Now, normally these receptors are ON. When these receptors are ON they are inhibiting lypolysis in all of these areas…keeping you from burning fat naturally in those areas!

Alpha-yohimbine inactivates these receptors, which will allow lypolysis to continue from beta-adrenoceptors. Through these mechanisms, you target both subcutaneous fat loss, the fat on the outside of your abs that is the hardest to lose, and visceral fat loss, the fat underneath your abs.

Now regular yohimbine blocks these alpha-2 receptors as well, but the problem is it also blocks alpha-1 receptors which is bad. This will actually stop lipolysis. So basically, regular yohimbine is doing very little in terms of actual fat loss, but its giving a lot of side effects to make you think it is.

Alpha-yohimbine has 50 times less affinity for this receptor, which compared to regular yohimbine is like night and day.

[G-Roy]

just orderd some alpha T2 sunday night, hoping it live sup to the hype.

[Natural Disaster]

Be sure to let us know

[jobuddha]

can anyone give us an update as to how well this is working for them?

[iron addict]

No one needs to do that, this is an extremely tried and true chem. It didn't come out yesterday, it has been on the market for at LEAST 7-8 years. It works assuming the rest of your diet is in place.

IA