Dobermann
08-23-2006, 02:19 AM
Trouble,
Here is an extract from a post on AL about why oral 7-keto-DHEA is not a good idea.As it's one of the supp's you recomend for the HG, would you concur thats it's better taken topically or not at all in it's oral form?
"Furthermore, with oral usage, we suppress 11-beta-HSD-1 activity in the liver. This increases the output of the inactive, dehydrogenase product, cortisone in the body, thus lowering systemic cortisol. This is good right?? Nope. Unfortunately, this results in an increase in systemic cortisone to serve as substrate for formation of the dreaded cortisol in the oxoreductase-only adipocyte and other tissues.
Worse, yet, as we alluded to, the 7-keto will be converted to the 7-alpha-OH compound, which will enter the bloodstream, and increase the reductase activity of the 11-beta-HSD complex, thus INCREASING formation of cortisol from cortisone in peripheral tissues such as adipose and muscle, as well as in the brain, where it will reek havoc, on the long-term functioning of the system."
Here is an extract from a post on AL about why oral 7-keto-DHEA is not a good idea.As it's one of the supp's you recomend for the HG, would you concur thats it's better taken topically or not at all in it's oral form?
"Furthermore, with oral usage, we suppress 11-beta-HSD-1 activity in the liver. This increases the output of the inactive, dehydrogenase product, cortisone in the body, thus lowering systemic cortisol. This is good right?? Nope. Unfortunately, this results in an increase in systemic cortisone to serve as substrate for formation of the dreaded cortisol in the oxoreductase-only adipocyte and other tissues.
Worse, yet, as we alluded to, the 7-keto will be converted to the 7-alpha-OH compound, which will enter the bloodstream, and increase the reductase activity of the 11-beta-HSD complex, thus INCREASING formation of cortisol from cortisone in peripheral tissues such as adipose and muscle, as well as in the brain, where it will reek havoc, on the long-term functioning of the system."